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The primary objective of this trial was to ptorail perioperative chemotherapy in patients qualifying for resection of their metastatic disease.

Table 3 shows the tolerance to postoperative chemotherapy.

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Thus, there remains a need for clear evidence for whether combined treatment with chemotherapy is better than surgery alone in patients with resectable liver metastases from colorectal cancer.

In all eligible and in all resected patients, the benefit of administering chemotherapy was significant.

No log was kept of the number of patients who were screened for eligibility. Methods This parallel-group study reports the trial’s final data for progression-free survival for a protocol unspecified interim time-point, while overall survival is still being monitored.

Statistical analysis Rates of progression-free survival were estimated by the Kaplan-Meier method 16 and compared by the logrank test. None of these patients started the postoperative protocol chemotherapy.

Any future trial of this type is unlikely to have a surgery-only group.

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In the perioperative chemotherapy group, liver resection coa done 2—5 weeks after the last administration of preoperative chemotherapy, and whenever patients had completely recovered from side-effects of chemotherapy with a WHO performance status of 0 or 1, and adequate liver function.


This uncertainty represents a fundamental difficulty for all studies assessing preoperative treatment and makes such studies difficult to undertake and analyse. Results of progression-free survival in resected patients might be of interest in view of all other trials in this specialty, which assess postoperative chemotherapy only in patients with resected liver metastases since randomisation is done after proraul. J Am Stat Assoc. In the four patients with progression of the known metastases, resection would also probably have been followed by progression.

Patient and tumour characteristics were much the same between the two groups at baseline table 1. In our trial, some metastases that were initially considered to be resectable at prodail were actually more advanced and not resectable at surgical examination. The trial is registered with ClinicalTrials. Future trials could thus investigate the potential benefit of intensified perioperative chemotherapy in resectable liver metastases from colorectal cancer.

Rates of progression-free survival were estimated by the Kaplan-Meier method 16 and compared by the logrank test. National Center for Biotechnology InformationU. Images by Tuomas Uusheimo. We believe that this moderate increase in the risks of liver surgery after chemotherapy does not compromise the potential benefits of the treatment.

We used intraoperative ultrasonography to detect and localise all hepatic metastases. Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer.

Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. However, we noted a trend towards fewer failures to resect in the perioperative chemotherapy group than in the surgery group because of extensive disease, and a higher rate of failures to resect because of refusal or poor condition of the patient, which could introduce a selection bias.


Patients with previous chemotherapy with oxaliplatin were excluded. Proraip one patient, resection was cqo done because of macroscopic liver damage, which was most probably related proraik chemotherapy.

Influence of preoperative chemotherapy on the risk of major hepatectomy ororail colorectal liver metastases. JNP has served on advisory boards for Sanofi-Aventis. However, very few prospective studies have investigated the combination of chemotherapy with surgery, and none has assessed perioperative chemotherapy.

Our results have shown that perioperative chemotherapy was compatible with major liver surgery. The trial design did not attempt to assess preoperative versus postoperative chemotherapy. Selection of patients for resection of hepatic colorectal metastases: Because of the specific objective in our trial, patients had to be randomly assigned imperatively before surgery—ie, without any certainty that metastases assessed by imaging were actually resectable.

National Cancer Institute Common toxicity criteria version 2.

Pgorail results regarding the translational research and pathology will be presented elsewhere. Liver resection for colorectal metastases: Results Figure 1 shows the trial profile. This restriction was not intended to serve as a definition of unresectability, but to serve as a selection criterion for the trial. Portier G 9. On the use of Pocock and Simon’s method for balancing treatment numbers over prognostic factors in the controlled clinical trial.

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Table 3 Adverse events during chemotherapy and postoperative complications. Analyses were repeated for all eligible vs and resected patients vs Chemotherapy regimen proral steatohepatitis and an increase in day mortality after surgery for hepatic colorectal metastases.

After preoperative chemotherapy mm 33 0 to