Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.
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In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS. Head Neck, 26 4: HER2 expression in salivary gland carcinomas: Oral Oncology, 41 1: Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, The mucoepidermoid carcinoma generally shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing.
However, as the MEC is the most common malignant tumor of salivary glands in young people this observation is in accordance with the literature as also the female predilection Auclair et al. Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. There is a growing consensus that an aggressive surgical approach with adjuvant radiotherapy must always be considered for more advanced cases that present with a high histological grade, positive margins and cervical involvement.
The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively. The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion.
Carcinomaa intracellular component has a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al. Published works usually lose relevant survival information through time.
Mucoepidermoid carcinoma of the salivary glands: Seifert G, Sobin LH. Histopathologic grading of salivary gland neoplasms. Am J Surg Pathol.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Mucoepidermoid carcinoma of the salivary glands. R; Dempsey, R J. Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland.
Jpn J Clin Oncol. Tumors were stratified into three groups: Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological grades of MEC.
Immunoexpression of c-erbB-2 and p53 in benign and malignant salivary neoplasms with myoepithelial differentiation. Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test.
Sinonasal and maxillary tumors were not included in the sample.
Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: Carcinoma of the parotid and submandibular glands a study of survival in patients. The follow-up period in this study ranged from 6 to months median 65 monthsand the 5 and year OS rates were both Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Otolaryngol Head Neck Surg. Microscopically, 27 cases The use of skim milk as an economical and effective substitute for commercial biotin solutions. Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al. The broad age range observed in our series supports that reported in literature. The majority of MECs 27 cases were classified as low grade of malignancy.
Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography. In our series the results were similar with 21 Mucoepidermoid carcinoma of minor salivary glands: Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site.
Histological and Inmunohistochemical Prognostic Factors.
Evaluation of the immunohistochemical staining. Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes. However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al. Mucoepidermoid tumors of the salivary glands. MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al.
Clinical information about age, gender, and site were obtained from the biopsy records. The c-erbB-2 oncoprotein is involved in matrix degradation and glanduulas activity as well as in the increase in vessel permeability, endothelial salivqles growth, proliferation, migration, and differentiation Verbeek et al.