When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.

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The MIC 90 values of vancomycin, daptomycin and linezolid were in the range 0. Implication coryhebacterium ermX genes in macrolide and telithromycin resistance in Corynebacterium jeikeium and Corynebacterium amycolatum.

Exposure to fluoroquinolones selects for spontaneous mutants in large bacterial populations, including those that colonize the skin and mucous membranes such as corynebacteria. L-Lysine production is specific to C. Her vital signs were unstable; hence, she was immediately admitted to the intensive care unit ICU. Clin Microbiol Rev ; Resistance to quinolones in Corynebacterium spp.

By using this site, you agree to the Terms of Use and Privacy Policy. Corynebacterium striatum, laryngeal carcinoma, nosocomial pathogen.

Corynebacterium – Wikipedia

Luna VA, et al. Susceptibility to aminoglycosides and distribution of aph and aac 3 -XI genes among Corynebacterium striatum clinical isolates.

Two pairs of isolates assigned to pulsotype E showed the same resistance profile. The higher level of moxifloxacin resistance in our strains suggest the existence of corynebactsrium resistance mechanism additional to mutations in gyrA. Comparative analysis of corynebacterial genomes has led to the identification of several conserved signature indels which are unique to the genus. Skin colonization by Corynebacterium groups D2 and JK in hospitalized patients.


Baio PV, et al. Van Hoek AH, et al.

Corynebacterium striatum: a diphtheroid with pathogenic potential.

Among the 31 MDR isolates, 19 resistance profiles could be distinguished. The term “diphtheroids” is used to represent corynebacteria that are non pathogenic ; for example, C. Abstract A year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure. Primers used to amplify the above mentioned genes are listed in Supplementary Table S1.

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Performance Standards for Antimicrobial Susceptibility Testing. The anatomical sites of specimens from whom the 63 C. In our strains, single amino-acid substitutions in position 87 of the GyrA protein generated ciprofloxacin resistance but double mutations in the gyrA gene leading to changes in positions 87 and 91 were necessary for high level resistance to ciprofloxacin and moxifloxacin.

This work highlights the high prevalence of multi-resistant strains and resistance genes among the C. PCR reactions were performed as previously described Aminoglycosides are used as complementary antibiotics to treat serious infections caused by diphtheroids. Clinical microbiology of coryneform bacteria. In two strains no changes in their QRDRs were detected, indicating that resistance was mediated by a different mechanism.

They are aerobic or facultatively anaerobicchemoorganotrophs.

A year-old woman was brought to our emergency department because of exertional dyspnea due to severe left ventricular functional failure. Please review our privacy policy. This page was last corynebadterium on 13 Decemberat Epidemiological investigation of a nosocomial outbreak of multidrug-resistant Corynebacterium striatum at one Belgian university hospital.

Corynebacterium striatum Bacteremia Associated with a Catheter-Related Blood Stream Infection

Resistance to fluoroquinolones in Corynebacterium spp. It is more common in developing countries [20] It corynebafterium occasionally infect wounds, the vulvathe conjunctivaand the middle ear. Multidrug-resistant, extensively drug-resistant and pandrug-resistant corynebacteriu, Corynebacterium striatum is an emerging nosocomial pathogen associated with wound infections, pneumonia and meningitis.


Medically relevant Corynebacterium species include Corynebacterium diphtheriaethe primary cause of diphtheria, and the non-diphtherial corynebacteria, which are part of the normal flora of the skin and mucous membranes. Pathogenic species in other animals include C. There are several reports of C.

The gene aac 3 -XI was found in 7 isolates. This is a report of an unusual case of wound infection in a patient with laryngeal carcinoma.

PFGE is considered the gold standard in epidemiological studies of pathogenic microorganisms, providing important insights into their population structure Published online Aug No bacteria species could be identified at this time. Identification, Clinical Relevance, and Antibiotic Susceptibility”.

Diagnostic Microbiology and Infectious Disease. Clinical and bacteriological analyses of bacteremia due to Corynebacterium striatum.

Sources of specimens from whom C. Superti SV, et al. However, in recent years, they have been reported as emerging coryhebacterium pathogens in immunocompromised patients with end-stage cancer, etriatum malignancy, and critical condition [ 2 ]. We investigated the susceptibility of 63 C. Daptomycin has also been proven to be active against C. The sequences of the QRDR region of the gyrA gene of 21 isolates categorized as resistant or intermediate to fluoroquinolones were compared to that of the quinolone-susceptible C.