HYVET TRIAL PDF

Keywords: elderly, hypertension, HYVET, older adults, treatment Despite this, a trend analysis from the EWPHE trial suggested that the. The Hypertension in the Very Elderly Trial (HYVET) is a multicentre, open, randomised, controlled trial. The aim of this trial is to investigate the effect of active. Drugs Aging. ;18(3) Hypertension in the Very Elderly Trial (HYVET): protocol for the main trial. Bulpitt C(1), Fletcher A, Beckett N, Coope J.

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At 2 years, there were no biochemical differences in serum potassium, uric acid, glucose, or creatinine, although Dr. The aim of this trial is to investigate the effect of active treatment on stroke incidence in hypertensive patients over the age of 80 years.

This enhanced recruitment rates and led to the inclusion of subjects with isolated systolic hypertension ISH.

Based trkal the originally published data, at a median follow-up of 1. Secondary outcomes included rates of fatal stroke, all-cause mortality, and CV events.

Dr Peter Sleight of Oxford in the UK asked whether this was related to cerebrovascular events, but Dr Peters thought the sample size of patients in this group was insufficient to generate an answer from the HYVET data.

Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in triak HYVET.

Support Center Tgial Center. This review provides an overview of the Hypertension in the Very Elderly Trial whilst also discursively evaluating the latest data.

Hypertension in the Very Elderly Trial (HYVET): protocol for the main trial.

These hyfet have been chosen as inexpensive and appropriate representatives of their therapeutic classes. Initially blood pressures were recorded with either a mercury sphygmomanometer or a validated automated device, but at the end of the trial a validated automated device was used in the majority of centres [ 13 ]. Out of the total population enrolled in HYVET, however, only 56 men and women were age 90 years or older.

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Allowing for all fractures, regardless of whether they were incident, validated fractures or not, resulted in an adjusted HR of 0.

When analyzing the 90 incident, validated fractures 38 in the active group; 52 in the placebo group and adjusting for baseline risk factors, a HR of 0. Br J Clin Pharmacol. Subjects were then randomized to one trixl two treatment arms, the thiazide like diuretic, indapamide sustained release, 1.

HYVET – Wiki Journal Club

Given the log yyvet relationship between systolic blood pressure and clinical outcomes, the mortality and morbidity benefits seen in the trial might be a feature of systolic BP control, particularly in ISH, as opposed to achieved systolic and diastolic blood pressure. Results of the pilot study for the hypertension in the very elderly trial.

Again, differences were seen for all-cause mortality 47 deaths; HR 0. However, at the time of the final intention-to-treat analysis in Octoberthis significant reduction in the primary outcome measure failed to show statistical significance — the reasons for which have never been elaborated.

Whilst each additional GDS point at baseline also increased these risks, the study was not designed to evaluate this association. Starting dosage for bendroflumethiazide and lisinopril is 2. However there was a non-significant rise in all cause mortality RHR 1.

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Immediate and late benefits of treating very elderly people with hypertension: Antihypertensive drugs in very old people: The initial inclusion criteria demanded both systolic and diastolic hypertension SDH mean systolic BP — mmHg; mean diastolic BP 90— mmHgoff treatment, during a 2 month yhvet in period.

Hypertension In The Very Elderly Trial (HYVET): Lower Is Better, But Not Too Low

Introduction The s saw publication of landmark data demonstrating the benefits of anti-hypertensive therapy [ 1 — 3 ]. Stepwise treatment consisted of triial diuretic indapamide sustained release 1.

However, with the passage of time, a progressive effort has been made to expand the evidence base for treatment in older adults. Author information Article notes Copyright and License information Disclaimer. The trial steering group also published an analysis evaluating the association of depression with cardiovascular mortality and morbidity, all-cause mortality and incident dementia. The role of blood pressure control in preventing complications of hypertension.

The primary endpoint of HYVET was any fatal or nonfatal stroke, with secondary endpoints including all-cause mortality, cardiovascular mortality, cardiac death, and death from stroke. There were also significant reductions in rates of other secondary outcomes including fatal stroke, HF, and CV events. In looking at the presence or absence of previous cardiovascular disease, hhvet men and women out of the entire HYVET population had any prior CVD.

Early trials in the field of hypertension focused on adults in their fifties and sixties.