ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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Creatine supplementation in patient groups. Still focusing at cellular level, NO seems to potentiate the proliferation of satellite cells, present in skeletal muscle fascicles, exerting a positive stimulus to muscular hypertrophy.

In what concerns nitrate supplementation, there are several ways of consumption, such as beetroot juice, spinach, sodium or potassium nitrate as acute regimes in trained subjects. The purpose of this article is to provide an overview of the accumulating research evidence concerning the role played by NO and its forming compounds in the physiological responses to exercise and sports performance. However, Poortmans and Francaux 92 did not find any effect of creatine supplementation on kidney function in healthy athletes.

Active athletes are known to have increased protein needs and, in fact, beneficial effects of arginine supplementation on muscle strength may be minimal in young healthy men who are already eating plenty of protein [ 735 ]. The ergogenic potential of this pathway has received considerable attention and has wide clinical applicability. One of the reasons for the lack of performance improvements following potejtial nitrate ingestion in endurance-trained athletes may be due to higher baseline levels of NO [ 8 ].

The exact protocol was then repeated in the same subjects, except that only the essential amino acids EAAs were given leucine, isoleucine, valine, methionine, lysine, phenylalanine, threonine, histadine. Sports Medicine41 3 Interestingly, NO production occurring at vascular levels is directly related to a rise in shear stress, while the increased blood flow induced by exercise provokes itself a rise in shear stress, creating, thus, a relationship between exercise, increased blood flow and endogenous NO production [ 10 ].

Due to the multiple roles attributable to L-Arginine, its supplementation is likely to result in increased metabolism via pathways other than NO synthesis, thus, other effects via NO-independent mechanisms may also play a role [ 24 ].


Nitric Oxide26 4 The primary method of increasing NO and inducing vasodilation, however, is through the activation of Nitric Oxide Heslthy NOS located in endothelial cells.

The mixed supplementation casts doubt on the validity of these conclusions. L-arginne though L-Arginine supplementation has been frequently linked to metabolic diseases, only a few studies have been evaluating the effects of associating L-Arginine supplementation and physical workout on health outcomes [ 31 ].

These have been summarized in several previous reviews on l-arhinine topic 4660 — Moreover, NO has been shown to increase diastolic distensibility and has also been implicated in the negative inotropic effects derived from selective ET-B1 receptor stimulation, collectively with prostaglandins, independently of the direct actions of each endothelial agent [ 57 ].

Furthermore, there seems to be a dose-response relationship between NO 3 – intake and its ergogenic effects, while the association with oxygen consumption is not as evident [ 9 ].

However, ergoogenic this time, guidelines concerning Arginine supplementation in Weightlifters are just still speculative.

L-Arginine as a potential ergogenic aid in healthy subjects.

A reexamination of the effects of creatine hea,thy muscle protein synthesis in tissue culture. L-Arginine infusion increases glucose clearance during prolonged exercise in humans. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, bealthy the original author and source are credited.

Oral creatine supplementation and athletic performance: VO2max is a measure heapthy reflects maximal oxygen uptake. Finally, despite the fact that creatine is normally found in cardiac muscle, brain, and testes, these areas remain essentially unstudied with respect to oral creatine supplementation. The effect of l-arginine administration on muscle force and power in postmenopausal women.

The increase in muscle creatine content with supplementation is usually greatest in subjects with low initial concentration, whereas subjects with higher starting sa may experience little or no increase 43 However, the supplement was mixed with several other compounds including citrulline, vitamin E, and alpha lipoic acid; therefore, the authors could not conclude that the increase in anaerobic threshold was solely due to L-arg.

L-Arginine as a potential ergogenic aid in healthy subjects.

Historically, many different substances have been used as ergogenic aids in humans [ 6 ]. First, many of the Arg supplements reviewed were mixed with other compounds, most of which had their own ergogenic effects. L-arginine is a conditionally essential amino acid that has received considerable attention due to potential effects on growth hormone secretion and nitric oxide production.


NO, a labile and short half-life molecule present in many biological fluidsis one of the most widespread signaling molecules, participating in virtually every cellular and organic function in body [ 1213 ]. Recently, nitric oxide NO has emerged as a promising ergogenic aid by supplementation, leading to a revolution in pharmacological and physiological knowledge [ 8 ]. Nevertheless, some studies report acute cardiovascular modulation, particularly associated with high doses of intake 30 g maximumsuch as hypotension with compensatory tachycardia, reduced peripheral arterial resistance and increase in cardiac output [ 10 ].

Dietary NO 3 – increases time to task failure at high intensity exercise and reduces the time needed to achieve a certain distance in time trials [ 9 ].

Accordingly, the purpose of this review is to provide an overview on the accumulating evidence concerning not only the importance of NO and its associated precursors in exercise and sports performance, but also the inherent cardiovascular modulation during workout, as well as ascertain the possible benefits and hazards, never despising the crucial role ascribed to sports nutrition professionals. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans.

Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

Pharmacokinetics of l-arginine during chronic administration to patients with hypercholesterolaemia. Research Article Open Access.

In fact, although acute nitrate intake may rapidly influence vascular tone and peripheral tissue oxygenation, more time may be necessary to produce changes in mitochondrial and contractile proteins, and, consequently, influence exercise performance [ 2327 ].

Interestingly, the liver is capable of synthesizing considerable amounts of L-Arginine, yet this is completely reutilized in the urea cycle, being crucial to its normal function [ 22 ]. It has been suggested that a possible contribution to tissue reconstruction is NO activation after injury exerts an effect on the expression of myogenic regulatory factors MFRs, like myogenin that occur during recovery [ 32 ].