Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Andrews’ diseases of the skin: There is a strong statistical association of the paraneoplastic process with truly having an underlying malignancy. Sign in to save your leserr Sign in to your personal account. Both the neoplastic and paraneoplastic process began concurrently. Both the neoplastic and paraneoplastic processes have a parallel disease course i.

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Eruptive seborrheic keratoses have been reported in numerous other frelat scenarios including in patients with erythroderma, keser patients, HIV-infected patients, and transplant patients.

Cutaneous manifestations of internal malignancies: Patients will often complain of pruritus associated with these lesions. Although these lesions are typically rather easy to distinguish from other melanocytic neoplasms, the histopathological examination may be required for lesions lacking typical exam findings.

Retrieved 15 July Published by Wolters Kluwer – Medknow. On physical examination, multiple, 2- to 6-mm, seborrheic keratoses and numerous pigmented filariform papillomas were present on the neck and malar regions Trela.

Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. Multiple eruptive seborrheic keratoses on the a face and neck, b breast, and c back Click here to view. It may possibly be due to the same unknown factors that induce malignant acanthosis nigricans.


Leser–Trélat sign

Russell bodies Auer rod Bence Jones protein. J Am Acad Dermatol ; Introduction The sign of Leser-Trelat is considered to be a fairly rare lesrr cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses.

China Source of Support: Leser-Trelat sign with primary hepatic carcinoma. Our website uses eign to enhance your experience. The typical morphology of these lesions tends to vary extensively amongst patients and may present as a macule, papules, and plaques.

Sign of Leser-Trélat | DermNet NZ

There is no reported increased predilection amongst either sex or any race. Seborrheic keratoses of florid eruption.

To rrelat free multiple choice questions on this topic, click here. Eruptive seborrheic keratoses associated with erythrodermic pityriasis rubra pilaris. Obtaining a thorough history, review or systems, and physical examination may help direct the workup of the patient towards a certain malignancy. Patients with asymptomatic lesions require no further treatment for the seborrheic keratoses besides the treatment of their malignancy.

Although most associated neoplasms are gastrointestinal [4] adenocarcinomas stomachlivercolorectal and pancreasmalignancies of the breastlung[5] hrelat urinary tract[6] as well as lymphoid tissue, have been associated with this impressive rash. Am J Med ; Click on image for details. There does not appear to be an increased frequency of a trepat histopathological variation of seborrheic keratoses that correlates with the sign of Leser-Trelat.

Also, seborrheic keratoses may be confused with a plethora of other cutaneous growths lese verruca vulgaris, acrochordons, nevi, solar lentigos, lichenoid keratoses, and even cutaneous malignancies such as squamous cell carcinoma or melanoma. Indian J Dermatol Venereol Leprol ; Eponymous medical signs for oncology.


Dermatologic signs Paraneoplastic syndromes. Malignant acanthosis nigricans, tripe palms and the sign of Leser-Trelat, a hint to the diagnosis of early stage ovarian cancer: The sgin of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses.

Indian J Dermatol Venereol Leprol. PMC ] [ PubMed: Leser Trelat Sign – StatPearls. Show details Treasure Island FL: History and Trealt As previously mentioned, seborrheic keratoses are a nearly ubiquitous, benign skin lesion in patients greater than 40 years of age.

Views Read Edit View history. Any of these distinct variations may also become irritated or inflamed, displaying either squamous eddy formation spindled cells or lymphocyte infiltration, respectively. Create a free personal account to make a comment, download free lesrr PDFs, sign up for alerts and more.

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Lesions tend to resolve once the underlying cancer is treated. Sign in to make a comment Sign in to your personal account. Gharwan H, Gradon JD. If you have any concerns with your skin or its treatment, see a dermatologist for advice.